Netupitant / Palonosetron Hydrochloride Information

NETUPITANT; PALONOSETRON (net ue pi tant; pal oh NOE setron) is used to prevent nausea and vomiting caused by chemotherapy. It also helps prevent delayed nausea and vomiting that may occur a few days after your treatment.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: -kidney disease -liver disease -an unusual or allergic reaction to netupitant, palonosetron, fosnetupitant, dolasetron, granisetron, ondansetron, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Usually, you will take a dose 1 hour before the start of your cancer treatment on day 1 of each treatment cycle. This medicine may be taken with or without food. Do not take more often than directed. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

You will take only 1 dose prior to your cancer treatment on day 1 of a treatment cycle as directed. If you miss taking this dose, inform your cancer care provider.

What may interact with this medicine?

-certain medicines for cancer -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for fungal infections like ketoconazole and itraconazole -certain medicines for sleep -certain medicines that treat or prevent blood clots like warfarin -dexamethasone -fentanyl -linezolid -MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate -methylene blue (injected into a vein) -midazolam -rifampin -tramadol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -confusion -dizziness -fast, irregular heartbeat -fever and chills -loss of balance or coordination -seizures -sweating -swelling of the hands and feet -tremors -unusually weak or tired Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -constipation or diarrhea -headache -mild fatigue

This list may not describe all possible side effects. Call your doctor for medical advice about side effects.

Where should I keep my medicine?

Keep out of the reach of children. Store between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.