DIFLUNISAL is used to treat osteoarthritis, rheumatoid arthritis, or mild to moderate pain.
They need to know if you have any of these conditions: -asthma, especially aspirin sensitive asthma -coronary artery bypass graft (CABG) surgery within the past 2 weeks -drink more than 3 alcohol-containing drinks a day -heart disease or circulation problems like heart failure or leg edema (fluid retention) -high blood pressure -kidney disease -liver disease -stomach bleeding or ulcers -an unusual or allergic reaction to diflunisal, aspirin, other salicylates, other NSAIDs, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding
Follow the directions on the prescription label. Do not chew or crush the tablets. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply. Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.
Do not take this medicine with any of the following medications: -cidofovir -indomethacin -ketorolac -methotrexate -pemetrexed This medicine may also interact with the following medications: -acetaminophen -alcohol -antacids -aspirin and aspirin-like medicines -cyclosporine -diuretics -lithium -medicines for high blood pressure -medicines that affect blood platelets -medicines that treat or prevent blood clots like warfarin -NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen -steroid medicines like prednisone or cortisone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself. This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional. Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine. This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.
Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -changes in vision -chest pain -difficulty breathing or wheezing -nausea or vomiting -redness, blistering, peeling or loosening of the skin, including inside the mouth -slurred speech or weakness on one side of the body -unexplained weight gain or swelling -unusual bleeding or bruising -unusually weak or tired -yellowing of eyes or skin Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -diarrhea -dizziness -headache -heartburn.