MACRODANTIN (NITROFURANTOIN)

Macrodantin Description

Macrodantin is an antibiotic prescribed to treat infections of the urinary system caused by certain bacteria, namely E. coli, Enterobacter cystitis, Enterococcus, Klebsiella, and Staphylococcus aureus. Depending on the strength your doctor has prescribed, Macrodantin can be bacteriostatic at 50mg or bactericidal at 100mg. Bacteriostatic means that Macrodantin will limit the growth and reproduction of the microorganisms. Your immune system also helps to control the activities of microorganisms. Bactericidal strength Macrodantin inhibits the production of the microorganisms’ cell walls so they die.

How This Antibiotic Deals with Bacteria

Macrodantin or generic Nitrofurantoin inhibits the bacteria’s ability to make new proteins which are essential for their growth by interfering with protein production and replicating DNA. As long as they cannot grow or divide, their numbers will not increase so your immune system is able to fight the bacteria. At a higher dosage, Macrodantin induces cell death and the bacteria are unable to reproduce so their numbers fall quickly as they perish. The generic alternative is not manufactured by the company that makes the brand product.

Conditions Treated by Macrodantin

Urinary tract infections (UTIs) seem to affect women more so than men. This infection is usually started by bacteria that live in and on our bodies. It is believed that because women have a shorter urethra and its close proximity to vaginal and anal openings, they are more susceptible to a UTI. Some people that use a catheter for extended periods of time are also more prone to getting a UTI. Although catheters are sterilized in their packaging, once inserted into the urethra, the small opening is a perfect way for bacteria to find their way to your urinary tract.

Our bodies host many bacteria which do not usually cause infections. However, if your immune system is weakened by illness or disease, you are unable to control the bacteria and they can cause a variety of infections, including in your urinary tract. If you are experiencing frequent urination, pain or burning when you urinate, strong smelling or cloudy urine, or abdominal pains, you should seek medical attention right away.

Before Macrodantin is Prescribed to You

Ask your doctor about the safety of taking Macrodantin if you are pregnant, may become pregnant, or are breast feeding. Discuss other medical conditions or allergies you have and list any OTC or Rx drugs you are taking, including herbal remedies or dietary and vitamin supplements. Your doctor can then determine if Macrodantin is the right medication for you.

Macrodantin Precautions and Proper Use

Until you know how Macrodantin will affect you, avoid driving and other activities that may be unsafe if you are not alert. Do not take any antacids that contain magnesium trisilicate as this could interfere with the efficacy of Macrodantin. You should not stop taking Macrodantin even if you feel well as there is a chance some bacteria have not died yet and they can start up another infection once the medicine is no longer being taken.

Possible Side Effects of Macrodantin

• Headache
• Loss of appetite
• Mild diarrhea