Isoniazid / Rifampin / Pyrazinamide Information

ISONIAZID; PYRAZINAMIDE; RIFAMPIN is a combination of three antibiotics. It is used to treat tuberculosis (TB). It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: -diabetes -gout -HIV or AIDS -if you often drink alcohol -kidney disease -liver disease -poor nutrition -tingling of the fingers or toes, or other nerve disorder -wear contact lenses -an unusual or allergic reaction to isoniazid, rifampin, rifabutin, pyrazinamide, other medicines, foods, dyes or preservatives -pregnant or trying to get pregnant -breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, either 1 hour before or 2 hours after food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 15 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications: -atomoxetine -certain antiviral medicines for HIV or AIDS -dronedarone -green tea -levodopa -MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate -procarbazine -ranolazine -sirolimus -voriconazole This medicine may also interact with the following medications: -acetaminophen -antacids -atovaquone -barbiturates like phenobarbital -beta-blockers like metoprolol and propranolol -calcium channel blockers like diltiazem, nifedipine and verapamil -certain antibiotics like ciprofloxacin -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for diabetes, like glipizide or glyburide -certain medicines for fungal infections like fluconazole, ketoconazole and itraconazole -certain medicines for irregular heart beat like disopyramide, mexiletine, quinidine -certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, valproic acid -certain medicines for sleep -certain medicines that treat or prevent blood clots like warfarin -chloramphenicol -clarithromycin -clofibrate -cyclosporine -dapsone -diazepam -digoxin -doxycycline -enalapril -female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections -haloperidol -levothyroxine -methadone -narcotic medicines for pain -quinine -sulfamethoxazole; trimethoprim -steroid medicines like prednisone or cortisone -tacrolimus -theophylline

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery. This medicine can color your teeth, urine, sweat, tears, and mucous. The color may stain your teeth for good. The color in tears may also stain soft contact lenses for good. If you wear contact lenses, ask your doctor or health care professional when you can use your lenses again. You may need blood work done while you are taking this medicine. Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. This medicine may cause a decrease in vitamin D and vitamin B6. You should make sure that you get enough vitamins while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -bloody or watery diarrhea -breathing problems -changes in vision -feeling faint or lightheaded, falls -fever -pain, tingling, numbness in the hands or feet -redness, blistering, peeling or loosening of the skin, including inside the mouth -signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose -signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine -signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin -unusually weak or tired Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -bone pain -confusion -diarrhea -dizziness -drowsiness -headache -joint pain -loss of appetite -nausea, vomiting -swelling of the ankles, feet, hands