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REGORAFENIB (RE goe RAF e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat colorectal cancer, gastrointestinal stromal tumors (GIST), and liver cancer.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions: -bleeding disorders -heart disease -high blood pressure -liver disease -recent surgery -an unusual or allergic reaction to regorafenib, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not take it more often than directed. Take this medicine with food. Do not take with grapefruit juice. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
This medicine may interact with the following: -carbamazepine -irinotecan -itraconazole -ketoconazole -phenobarbital -phenytoin -posaconazole -rifampin -St. John's Wort -telithromycin -voriconazole -warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop. You may need blood work done while you are taking this medicine. Do not become pregnant while taking this medicine or for 2 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 2 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it. If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine. Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.
Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -bloody or black, tarry stools -breathing problems -changes in vision -chest pain or chest tightness -confusion -dizziness -feeling faint or lightheaded -high fever -light-colored stools -nausea, vomiting -red or dark-brown urine -red spots on the skin -right upper belly pain -seizures -severe headache -sores on the hands or feet -spitting up blood or brown material that looks like coffee grounds -stomach pain -unusual bruising or bleeding from the eye, gums, or nose -unusually weak or tired -yellowing of the eyes or skin Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -diarrhea -hoarseness -loss of appetite -sore throat -tiredness -weight loss
This list may not describe all possible side effects. Call your doctor for medical advice about side effects.
Keep out of the reach of children. Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Throw away any unused medicine 7 weeks after opening the bottle.