You have no items in your shopping cart.

Product was successfully added to your shopping cart.

Quick Overview

Trifexis (Spinosad / Milbemycin oxime)

Trifexis (Spinosad / Milbemycin oxime)

Product Name Price Qty    
Comfortis Plus for Dogs 10.1-20lbs (4.6 to 9kg)
270mg/4.5mg Tablet (Chewable)

(℞) Prescription required.
Panoramis for Dogs 40.1 to 60 lbs (18.1 to 27kg)
810mg/135mg Tablet (Chewable)

(℞) Prescription required.
Treclin Gel
1.2%/0.025% Gel

(℞) Prescription required.

Availability: In stock



Trifexis Description

As responsible pet owners, you rely on your veterinarian to keep you informed about the health of your dog, including how to avoid fleas and internal parasites from causing illness and discomfort to your fur-friend. Trifexis is a once-a-month beef-flavored tablet that can protect your dog from fleas, heartworm, round worm, hookworm, and whipworm; all of which can cause scratching, chewing, weight loss, and heart/lung damage. Trifexis is taken orally so there’s no need to worry about chemicals on their skin or having to segregate them from the family so no one touches the treated area.

How the Active Ingredients Work

Your pet should be tested for heartworm before starting Trifexis so the adults can be dealt with separately. Once your veterinarian has established that there are no pre-existing concerns with your canine, feed one Trifexis tablet once a month and put your mind at ease that not only is your pet protected, your family is as well from flea bites and ingesting any parasite larvae.

When your dog is bitten by a flea or mosquito, they ingest Spinosad/Milbemycin Oxime, the active ingredients of Trifexis. Together, they will act on the parasite’s nervous system by causing their muscles to flex uncontrollably. This eventually causes paralysis, followed by their death.

More About Heartworm

When an infected mosquito bites a dog, the infective larvae that has been living in the mosquito are released through the tiny bite wound where they get migrate into the bloodstream and take 6-7 months to mature, mate, and the offspring are released. You may notice your dog begins to tire easily and a deep cough develops.

Without treatment, the symptoms become more severe and the dog will eventually expire. Be vigilant with your canine and have your vet check for existing heartworm. If everything is ok, then start Trifexis right away before mosquito season and before you are left with the cost of treating heartworm. Your pet will be happy, healthy, and parasite-free.

Before Starting Trifexis

Trifexis is available in five different strengths, depending on the weight of your dog or puppy eight weeks and older and at least five pounds, keeping in mind you will need to monitor the puppy and administer the proper dosage as he/she grows. Tell your vet about other medical conditions your pet may have or is being treated for to make sure that Trifexis is safe for you to administer. Do not give your breeding female Trifexis unless you have checked with your veterinarian first that it will not harm any unborn pups.

Proper Use and Recommendations for Trifexis

Trifexis is not approved for use in cats or kittens. Talk to your vet about parasite control for your felines. Keep Trifexis away from children so they are not inclined to think they are treats. Ask your vet if Trifexis is safe for all breeds of dogs as some anti-parasitic drugs could make your pet more sensitive to the side effects or active ingredients. Watch for signs of trembling, staggering, or pressing their head against a wall while being treated with Trifexis and seek immediate medical assistance.

Possible Side Effects of Trifexis

  • Vomiting
  • Lethargy
  • Decreased appetite