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Xtandi is an androgen receptor inhibitor drug your doctor may prescribe for men with prostate cancer that are no longer responding to other treatments to lower testosterone levels. Androgens are a group of hormones that includes testosterone and are believed to be the reason for prostate cancer cell growth. As an inhibitor of the androgen receptors, Xtandi works by decreasing how often testosterone (androgen) connects to the androgen receptor. This results in a reduction of the tumor’s growth, but it is not a cure for prostate cancer.
This medication is not to be handled or taken by women, nor duringa pregnancy or if you could become pregnant by a man that is taking Xtandi, so it is essential that proper contraception is used and continued for at least 3 months after treatment has stopped.
ENZALUTAMIDE blocks the effect of the male hormone called testosterone. This medicine is used for certain types of prostate cancer.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions: -bone problems -brain tumor -head injury -heart disease -history of stroke -seizures -an unusual or allergic reaction to enzalutamide, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding
Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Follow the directions on the prescription label. Do not cut, crush, or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and skip your missed dose. Do not take double or extra doses.
This medicine may interact with the following medications: -alfentanil -bosentan -certain medications for seizures like carbamazepine, phenobarbital, and phenytoin -cyclosporine -dihydroergotamine -efavirenz -ergotamine -etravirine -fentanyl -gemfibrozil -midazolam -modafinil -nafcillin -omeprazole -pimozide -quinidine -rifabutin -rifampin -rifapentine -St. John's Wort -sirolimus -tacrolimus -warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
This medicine should not be used in women. Men should not father a child while taking this medicine and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Women who are pregnant or may get pregnant must not handle enzalutamide capsules, as they could harm an unborn baby. Due to a risk of seizures with enzalutamide therapy, use caution when engaging in activities that could result in serious harm to yourself or others if you pass out.
Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -changes in vision -chest pain or tightness -confusion -falls -loss of memory -seizures -sudden numbness or weakness of the face, arm or leg -trouble speaking or understanding -trouble walking, dizziness, loss of balance or coordination Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -blood in the urine -breathing problems -diarrhea -dizziness -headache -joint pain -pain, tingling, numbness in the hands or feet -swelling of the ankles, feet, hands -unusually weak or tired
This list may not describe all possible side effects. Call your doctor for medical advice about side effects.
Keep out of the reach of children. Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.